Can you take modvigil with oxycodone?

Taking Modvigil 200 mg with oxycodone should be done only under medical supervision. Modafinil can affect liver enzymes that may reduce oxycodone’s effectiveness or change how long it stays in the body. Oxycodone is a strong opioid that can cause drowsiness and breathing problems, while modafinil promotes wakefulness, so combining them may mask side effects or increase risks. Always tell your doctor about all medicines you take so they can adjust doses safely and monitor for interactions.